Escherichia coli is the most common cause of diarrhea in calves. This innovation offers the specific antibody against E. coli from bovine colostrums derived from vaccinated mother cows. However, in the gastrointestinal tract of older calves, the antibodies are very sensitive to digestive tract environment. Microencapsulation may protect immunoglobulin (colostral antibody) and increase its absorption in digestive system, thus it may be effective in controlling E. coli diarrhea in calves.